%0 Journal Article
%T Brunner¡¯s Gland Adenoma with High-Grade Dysplasia
%A Fariha H. Ramay
%A John C. Papadimitriou
%A Peter E. Darwin
%J Archive of "ACG Case Reports Journal".
%D 2018
%R 10.14309/crj.2018.81
%X Brunner¡¯s gland adenoma is a rare, benign, small-bowel neoplasm. In a few reported cases, it can cause gastrointestinal hemorrhage and can be associated with cellular atypia. We report an 84-year-old woman with a 12-mm Brunner¡¯s gland adenoma in the second part of the duodenum that was successfully removed with a saline injection-lift technique using a hot snare, followed by placement of clips to prevent postpolypectomy bleeding. Pathological examination revealed Brunner¡¯s gland adenoma with high-grade dysplasia and oncocytic features with negative resection margins. The patient recovered uneventfully. Brunner¡¯s gland adenoma is traditionally considered a benign lesion, and few cases in the published literature have reported Brunner¡¯s gland adenoma with dysplasia or neoplasia. This suggests a dysplastic stage in the natural history of Brunner¡¯s gland adenoma and questions the malignant potential of such lesions
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277137/