%0 Journal Article
%T Mouse Model for Assessing the Subchronic Toxicity of Organophosphate Pesticides
%A A. G. Gabibov
%A I. A. Dyachenko
%A I. V. Smirnov
%A O. G. Shamborant
%A O. N. Khokhlova
%A S. S. Terekhov
%A S. V. Panteleev
%A V. A. Kazakov
%A V. A. Palikov
%A V. D. Knorre
%A Yu. A. Mokrushina
%A Yu. A. Palikova
%J Archive of "Acta Naturae".
%D 2018
%X The development of antidotes to organophosphate poisons is an important aspect of modern pharmacology. Recombinant acetylcholinesterase and butyrylcholinesterase are effective DNA-encoded acceptors of organophosphate poisons and, in particular, pesticides. Here, we present the results of a study on the effectiveness of recombinant butyrylcholinesterase (BChE) in modeling organophosphate poisoning caused by oral administration of paraoxon at a dose of 2 mg / kg. The study showed a high activity of BChE as a protective agent for subchronic anticholinesterase poisoning in an in vivo model. The administration of BChE in a dose of 20 mg / kg allows one to avoid mortality, and also contributed to rapid recovery after model poisoning
%K butyrylcholinesterase
%K in vivo model
%K organophosphorus toxins
%K bioscavenger
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351027/