%0 Journal Article
%T Cyclic AC253, a novel amylin receptor antagonist, improves cognitive deficits in a mouse model of Alzheimer's disease
%A Aarti Patel
%A David MacTavish
%A David Westaway
%A Jeffrey Zajac
%A Kamaljit Kaur
%A Rachel Davey
%A Rania Soudy
%A Wen Fu
%J Archive of "Alzheimer's & Dementia : Translational Research & Clinical Interventions".
%D 2017
%R 10.1016/j.trci.2016.11.005
%X Amylin receptor serves as a portal for the expression of deleterious effects of amyloid ¦Â-protein (A¦Â), a key pathologic hallmark of Alzheimer's disease. Previously, we showed that AC253, an amylin receptor antagonist, is neuroprotective against A¦Â toxicity in vitro and abrogates A¦Â-induced impairment of hippocampal long-term potentiation
%K Amylin receptor
%K AC253 peptide
%K Alzheimer's disease
%K Amyloid ¦Â
%K In vivo imaging
%K Brain penetration
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651374/