%0 Journal Article
%T Influence of Repeated Senna Laxative Use on Skin Barrier Function in Mice
%A Kazuya Ooi
%A Keiichi Hiramoto
%A Satoshi Yokoyama
%A Yurika Yamate
%J Archive of "Annals of Dermatology".
%D 2017
%R 10.5021/ad.2017.29.4.414
%X Senna, one of the major stimulant laxatives, is widely used for treating constipation. Chronic senna use has been reported to be associated with colonic disorders such as melanosis coli and/or epithelial hyperplasia. However, there is no obvious information on the influence of chronic senna use on organs except for the intestine
%K Acetylcholine
%K Nitric oxide synthase type II
%K Senna extract
%K Skin hydration
%K Transepidermal water loss
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500705/