%0 Journal Article
%T Enrichment factors for clinical trials in mild-to-moderate Alzheimer's disease
%A Alireza Atri
%A Jeffrey L. Cummings
%A Jos¨¦ Luis Molinuevo
%A Lars Lau Raket
%A Lutz Fr£¿lich
%A Neli Boneva
%A Pierre N. Tariot
%J Archive of "Alzheimer's & Dementia : Translational Research & Clinical Interventions".
%D 2019
%R 10.1016/j.trci.2019.04.001
%X Heterogeneity of outcomes in Alzheimer's disease (AD) clinical trials necessitates large sample sizes and contributes to study failures. This analysis determined whether mild-to-moderate AD populations could be enriched for cognitive decline based on apolipoprotein (APOE) ¦Å4 genotype, family history of AD, and amyloid abnormalities
%K Alzheimer's disease
%K Clinical trial
%K Enrichment
%K Power
%K Biomarkers
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527908/