%0 Journal Article %T The Effect of Micro-Spicule Containing Epidermal Growth Factor on Periocular Wrinkles %A Chang-Deok Kim %A Cho-Ah Lim %A Hae-Eul Lee %A Jeong-Min Ha %A Jeung-Hoon Lee %A Jong-Cheon Ha %A Kyuboem Han %A Myung Im %A Young Lee %A Young-Joon Seo %J Archive of "Annals of Dermatology". %D 2017 %R 10.5021/ad.2017.29.2.187 %X Micro-needle patches have been recently used to increase skin permeability, which improves drug delivery, and for cosmetic purposes. However, these patches may often have limited efficacy due to insufficient skin penetration and reduced compliance caused by discomfort %K Epidermal growth factor %K Micro-spicule %K Wrinkles %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383744/