%0 Journal Article
%T First report of co-morbidity of pantothenate kinase-associated neurodegeneration and three types of chronic hemolytic anemias
%A Ebtessam H.K. El Melegy
%A Enas A.A. Abdallah
%A Hamed A. Alghamdi
%A Iman M. Talaat
%A Mohamed A. Alshahrani
%A Mohammed F. Aljabri
%A Mohammed Sarar
%J Archive of "Annals of Medicine and Surgery".
%D 2016
%R 10.1016/j.amsu.2015.10.015
%X Pantothenate kinase-associated neurodegeneration (PKAN), sickle cell anemia, and thalassemia are autosomal recessive disorders that can cause iron deposition in tissues during childhood. PKAN is characterized by accumulation of iron in the basal ganglia causing progressive extrapyramidal manifestations. Thalassemia and sickle cell disease can cause iron overload and deposition in tissues, including central nervous system
%K Pantothenate kinase-associated neurodegeneration
%K Eye of the tiger sign
%K Sickle cell disease
%K ¦Â-Thalaasemia
%K Hemosiderosis
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680082/