%0 Journal Article
%T Head to head comparison performance of 99mTc-EDDA/HYNIC-iPSMA SPECT/CT and 68Ga-PSMA-11 PET/CT a prospective study in biochemical recurrence prostate cancer patients
%A Anna Scavuzzo
%A Clara Santos-Cuevas
%A Francisco Osvaldo Garc¨ªa-P¨¦rez
%A Guillermina Ferro-Flores
%A Jenny Davanzo
%A Miguel A J¨ªmenez-R¨ªos
%A Sergio L¨®pez-Buenrostro
%A Sevasti¨¢n Medina-Ornelas
%A Zael Santana-R¨ªos
%J Archive of "American Journal of Nuclear Medicine and Molecular Imaging".
%D 2018
%X Positron emission tomography (PET) with prostate-specific membrane antigen (PSMA) has found widespread use for the diagnosis of biochemical recurrence of prostate cancer (PCa). Unfortunately, PET/CT is not as widely available; thus a PSMA-targeting compound for scintigraphy is of special interest. The aim of this study was to compare 99mTc-EDDA/HYNIC-iPSMA and 68Ga-PSMA-11 PET/CT qualitatively and semi-quantitatively. Twenty-three patients with metastatic PCa were underwent 99mTc-EDDA/HYNIC-iPSMA SPECT/CT followed by 68Ga-PSMA-11 PET/CT. Gleason score in all patients was obtained. Maximal standardized uptake value (SUVmax) and counts per organ, including the primary and metastatic tumor, were normalized and compared using Pearson¡¯s correlation test. Sites considered as positive have increased SUVmax and tumor-to-background ratio (TBR) in comparison with non-diseased organs/tissues (SUVmax =25.2¡À4.7, 18.4¡À1.6, 11.4¡À1.2 (P=0.037) from prostate, bone and lymph nodes versus TBR =35.9¡À45.2, 15.4¡À18.9, 19.1¡À51.7 (P=0.035) for prostate, bone and lymph nodes. 99mTc-HYNIC-iPSMA and 68Ga-PSMA-11 uptake values in the evaluation of the affected nodes were very similar, although their ranges ranged from 5-21 mm (12¡À7.6). Correlation coefficient was normalized between SUVmax and TBR, demonstrating r values for prostate of r2=0.731; for bone of r2=0.720; and lymph nodes of r2=0.864 (P<0.05 in all cases). Values and confidence interval at the 95% are supporting the equivalency of both parameters in primary tumor and metastases (prostate 95% CI=4.61, 4.38; bone tissue 95% CI=-2.21, 3.41 and lymph node 95% CI=4.67). We conclude that 68Ga-PSMA-11 PET/CT and 99mTc-EDDA/HYNIC-iPSMA SPECT/CT were comparable, supporting the use of 99mTc-EDDA/HYNIC-iPSMA in patients with progressive metastatic castration-resistant PCa
%K 99mTc-HYNIC-PSMA
%K SPECT/CT
%K biochemical recurrence prostate cancer
%K 68Ga-PSMA-11 PET/CT
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261875/