%0 Journal Article
%T Long Noncoding RNAs CUPID1 and CUPID2 Mediate Breast Cancer Risk at 11q13 by Modulating the Response to DNA Damage
%A Adrian P. Wiegmans
%A Amanda L. Bain
%A Andreas M£¿ller
%A Ann-Marie Patch
%A Brian S. Gloss
%A Bryan Day
%A Eloise Dray
%A Fares Al-Ejeh
%A Haran Sivakumaran
%A Joanna Crawford
%A John Pearson
%A Joshua A. Betts
%A Kristine M. Hillman
%A Kum Kum Khanna
%A Mahdi Moradi Marjaneh
%A Marcel E. Dinger
%A Melissa A. Brown
%A Michael B. Clark
%A Nenad Bartonicek
%A Nicola Waddell
%A Nicole Cloonan
%A Romain Trop¨¦e
%A Shivangi Wani
%A Shu W. Wen
%A Stacey L. Edwards
%A Stephen Kazakoff
%A Susanne Kaufmann
%A Timothy R. Mercer
%A Wei Shi
%A Yi Chieh Lim
%J Archive of "American Journal of Human Genetics".
%D 2017
%R 10.1016/j.ajhg.2017.07.007
%X Breast cancer risk is strongly associated with an intergenic region on 11q13. We have previously shown that the strongest risk-associated SNPs fall within a distal enhancer that regulates CCND1. Here, we report that, in addition to regulating CCND1, this enhancer regulates two estrogen-regulated long noncoding RNAs, CUPID1 and CUPID2. We provide evidence that the risk-associated SNPs are associated with reduced chromatin looping between the enhancer and the CUPID1 and CUPID2 bidirectional promoter. We further show that CUPID1 and CUPID2 are predominantly expressed in hormone-receptor-positive breast tumors and play a role in modulating pathway choice for the repair of double-strand breaks. These data reveal a mechanism for the involvement of this region in breast cancer
%K long noncoding RNAs
%K breast cancer
%K GWAS
%K 11q13
%K enhancer
%K DNA repair
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544418/