%0 Journal Article
%T Comparative transcriptomics across 14 Drosophila species reveals signatures of longevity
%A Alexey A. Moskalev
%A Andrei S. Avanesov
%A Byung Cheon Lee
%A Emily Porter
%A Marco Mariotti
%A Nadezhda Zemskaya
%A Roderic Guigo
%A Siming Ma
%J Archive of "Aging Cell".
%D 2018
%R 10.1111/acel.12740
%X Lifespan varies dramatically among species, but the biological basis is not well understood. Previous studies in model organisms revealed the importance of nutrient sensing, mTOR, NAD/sirtuins, and insulin/IGF1 signaling in lifespan control. By studying lifeŠ\history traits and transcriptomes of 14 Drosophila species differing more than sixfold in lifespan, we explored expression divergence and identified genes and processes that correlate with longevity. These longevity signatures suggested that longerŠ\lived flies upregulate fatty acid metabolism, downregulate neuronal system development and activin signaling, and alter dynamics of RNA splicing. Interestingly, these gene expression patterns resembled those of flies under dietary restriction and several other lifespanŠ\extending interventions, although on the individual gene level, there was no significant overlap with genes previously reported to have lifespanŠ\extension effects. We experimentally tested the lifespan regulation potential of several candidate genes and found no consistent effects, suggesting that individual genes generally do not explain the observed longevity patterns. Instead, it appears that lifespan regulation across species is modulated by complex relationships at the system level represented by global gene expression
%K aging
%K gene expression
%K lifespan
%K Drosophila
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052463/