%0 Journal Article
%T Long-term disease-free survival in surgically-resected oral tongue cancer: a 10-year retrospective study
%A A. LUCIANI
%A A. MACCARI
%A A. MARRA
%A A. SAIBENE
%A C. CODEC¨¤
%A D. FERRARI
%A D. RABBIOSI
%A F. BROGGIO
%A G. FELISATI
%A L. MONEGHINI
%A M. BLASI
%A M. VIOLATI
%A S. ZONATO
%J Archive of "Acta Otorhinolaryngologica Italica".
%D 2019
%R 10.14639/0392-100X-2336
%X Early and loco-regionally advanced oral tongue squamous cell carcinoma (OTSCC) can be treated by surgery alone or followed by adjuvant radiotherapy or chemoradiotherapy. Nevertheless, up to 40% of patients develop tumour relapse. The aim of our study is to investigate the clinical and pathological features associated with reduced disease-free survival (DFS) in a cohort of surgically-resected OTSCC patients. One hundred and six patients surgically resected for OTSCC were retrospectively identified from clinical records. DFS was calculated according to the Kaplan¨CMeier method and differences between variables were assessed with Log-Rank test. A multivariable Cox regression model was used to analyse the impact of different prognostic factors on DFS. After a median of follow-up of 8.9 years, 22 events, including 11 deaths, were observed. Overall, the 5-year DFS-rate was 87.4%. The presence of extra-nodal extension (p = 0.023) and perineural invasion (p = 0.003) were significantly correlated with shorter DFS (in univariate analysis). In multivariable analysis, extra-nodal extension and perineural invasion confirmed their role as independent prognostic factors associated with an increased risk of disease recurrence [hazard ratio (HR) 2.87, 95% CI 1.11-7.42, p = 0.03; HR 3.85, 95% CI 1.49-9.96, p = 0.006, respectively]. p16 and p53 expressions in tumour cells were detected in 12% (n = 9) and 46% (n = 40) of cases, respectively. No differences in DFS were observed between p16+ and p16- (p = 0.125) and between p53+ and p53- tumours (p = 0.213). In conclusion, radical surgery, eventually followed by adjuvant radiotherapy or chemo-radiotherapy, can achieve high cure rates in OTSCC. After long-term follow-up, perineural invasion and extra-nodal extension confirmed their role as prognostic factors associated with reduced DFS in OTSCC patients
%K Oral cancer
%K Tongue cancer
%K Head and neck squamous cell carcinoma
%K p53
%K p16 Tumori del cavo orale
%K Tumore della lingua
%K Tumori della testa e del collo
%K p53
%K p16
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522864/