%0 Journal Article
%T Embryonic Stem Cells©\Derived Exosomes Endowed with Targeting Properties as Chemotherapeutics Delivery Vehicles for Glioblastoma Therapy
%A Bi Chen
%A Guowen Hu
%A Haiyan Li
%A Juntao Zhang
%A Qing Li
%A Qingwei Zhu
%A Xiaozheng Ling
%A Xin Niu
%A Yang Wang
%A Yunlong Yang
%J Archive of "Advanced Science".
%D 2019
%R 10.1002/advs.201801899
%X Exosomes are nanosized membrane vesicles (30¨C100 nm) that can easily penetrate the blood¨Cbrain barrier, safely deliver therapeutic drugs, and be modified with target ligands. Embryonic stem cells (ESCs) provide abundant exosome sources for clinical application due to their almost unlimited self©\renewal. Previous studies show that exosomes secreted by ESCs (ESC©\exos) have antitumor properties. However, it is not known whether ESC©\exos inhibit glioblastoma (GBM) growth. In this study, the anti©\GBM effect of ESC©\exos is confirmed and then c(RGDyK)©\modified and paclitaxel (PTX)©\loaded ESC©\exos, named cRGD©\Exo©\PTX are prepared. It is then investigated whether the engineered exosomes deliver more efficiently to GBM cells versus free drug alone and drug©\loaded ESC©\exos using an in vitro GBM model and in vivo subcutaneous and orthotopic xenografts model. The results show that cRGD©\Exo©\PTX significantly improves the curative effects of PTX in GBM via enhanced targeting. These data indicate that ESC©\exos are potentially powerful therapeutic carriers for GBM and could have utility in many other diseases
%K blood¨Cbrain barrier
%K drug delivery system
%K exosomes
%K glioblastoma
%K human embryonic stem cells
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425428/