%0 Journal Article
%T Update on the pathophysiology and treatment of rhinogenic headache: focus on the ibuprofen/pseudoephedrine combination
%A A. CAMAIONI
%A A. CHIARUGI
%J Archive of "Acta Otorhinolaryngologica Italica".
%D 2019
%R 10.14639/0392-100X-1882
%X Rhinogenic headache is frequently encountered in clinical practice. Treatment of this condition should be based on a proper evaluation of its underlying pathophysiology. Fixed-dose combinations of two or more active agents, and specifically the combination of ibuprofen plus pseudoephedrine, have been shown to be more efficacious than either monotherapy. At present, an ibuprofen/pseudoephedrine fixed-dose combination is available as an over-the-counter drug. This paper reviews in detail the pathophysiology of rhinogenic headache and discusses the rationale for treatment of this condition with a fixed-dose ibuprofen/pseudoephedrine combination
%K Combination therapy
%K Ibuprofen
%K Pathophysiology
%K Pseudoephedrine
%K Rhinogenic headache Terapia combinata
%K Ibuprofene
%K Fisiopatologia
%K Pseudoefedrina
%K Cefalea rinogenica
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444167/