%0 Journal Article
%T Quantitation of CDH1 promoter methylation in formalin-fixed paraffin-embedded tissues of breast cancer patients using differential high resolution melting analysis
%A Abbas Jafarian-Dehkordi
%A Hamid Mir Mohammad Sadeghi
%A Javad Mohammadi-Asl
%A Mohammad Rabbani
%A Mojgan Naghitorabi
%A Shaghayegh Haghjooy Javanmard
%J Archive of "Advanced Biomedical Research".
%D 2016
%R 10.4103/2277-9175.183139
%X E-cadherin (CDH1) plays an important role in cell¨Ccell adhesion of epithelial tissues. Loss of E-cadherin expression can lead to loss of tissue integrity, metastasis, and cancer progression. Also loss of E-cadherin expression might be related to aberrant promoter methylation of the CDH1 gene. Many studies have been performed on CDH1 promoter methylation, especially in breast cancer. Although most of the studies have used qualitative methods for methylation analysis, this study is designed to quantitatively investigate CDH1 promoter methylation in breast cancer and its correlation with patients¡¯ clinicopathological features
%K Breast cancer
%K CDH1
%K FFPE
%K high resolution melting analysis
%K promoter methylation
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908786/