%0 Journal Article
%T Efficient Near Infrared Light Triggered Nitric Oxide Release Nanocomposites for Sensitizing Mild Photothermal Therapy
%A Jiangfeng Du
%A Jie Yu
%A Qin Gao
%A Shuang Zhu
%A Wenyan Yin
%A Xiao Zhang
%A Yuliang Zhao
%A Zhanjun Gu
%J Archive of "Advanced Science".
%D 2019
%R 10.1002/advs.201801122
%X Mild photothermal therapy (PTT), as a new anticancer therapeutic strategy, faces big challenges of limited therapeutic accuracy and sideİ\effects due to uneven heat distribution. Here, near infrared triggered nitric oxide (NO) release nanocomposites based on bismuth sulfide (Bi2S3) nanoparticles and bisİ\Nİ\nitroso compounds (BNN) are constructed for NOİ\enhanced mild photothermal therapy. Upon 808 nm irradiation, the high photothermal conversion efficiency and onİ\demand NO release are realized simultaneously. Due to the unique properties of NO, enhanced antitumor efficacy of mild PTT based on BNNİ\Bi2S3 nanocomposites is achieved in vitro and in vivo. Mechanism studies reveal that the exogenous NO from BNNİ\Bi2S3 could not only impair the autophagic selfİ\repairing ability of tumor cells in situ, but also diffuse to the surrounding cells to enhance the therapeutic effect. This work points out a strategy to overcome the difficulties in mild PTT, and has potentials for further exploitation of NOİ\sensitized synergistic cancer therapy
%K autophagy
%K mild photothermal therapy
%K NIR triggered
%K nitric oxide release
%K NOİ\sensitized synergistic therapy
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364593/