%0 Journal Article
%T Dietary Zinc Supplementation to Prevent Chronic Copper Poisoning in Sheep
%A Alexandre Coutinho Antonelli
%A Carolina Akiko Sato Cabral ArašČjo
%A Clara Satsuk Mori
%A Enrico Lippi Ortolani
%A Francisco Leonardo Costa Oliveira
%A Frederico Augusto Mazzocca Lopes Rodrigues
%A Marta Lšźpez-Alonso
%A Marta Miranda
%A Raimundo Alves Barršșto JšČnior
%A Rejane Santos Sousa
%J Archive of "Animals : an Open Access Journal from MDPI".
%D 2018
%R 10.3390/ani8120227
%X Sheep are susceptible to copper toxicosis, a deadly disease that usually occurs when the animals ingest large amounts of this mineral. Considering that the susceptibility of sheep to copper accumulation varies widely among breeds and from animal to animal., we evaluate whether Zn supplementation could be an option as a preventive measure to protect against hepatic Cu accumulation in sheep. Zn at 300 mg/kg dry matter (DM) is useful for preventing excessive hepatic Cu accumulation. Hepatic Cu accumulation is lower in animals receiving the Zn supplementation
%K chronic copper poisoning
%K toxicity
%K sheep
%K liver
%K metallothionein
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315410/