%0 Journal Article
%T How Much Does Inbreeding Reduce Heterozygosity? Empirical Results from Aedes aegypti
%A Jeffrey R. Powell
%J Archive of "The American Journal of Tropical Medicine and Hygiene".
%D 2017
%R 10.4269/ajtmh.16-0693
%X Deriving strains of mosquitoes with reduced genetic variation is useful, if not necessary, for many genetic studies. Inbreeding is the standard way of achieving this. Full-sib inbreeding the mosquito Aedes aegypti for seven generations reduced heterozygosity to 72% of the initial heterozygosity in contrast to the expected 13%. This deviation from expectations is likely due to high frequencies of deleterious recessive alleles that, given the number of markers studied (27,674 single nucleotide polymorphisms [SNPs]), must be quite densely spread in the genome
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239684/