%0 Journal Article
%T A 5-Methylcytosine Site of Growth Differentiation Factor 9 (GDF9) Gene Affects Its Tissue-Specific Expression in Sheep
%A Fukuan Li
%A Hui Wang
%A Qiuyue Liu
%A Ran Di
%A Shengjin Lv
%A Wenping Hu
%A Xiangyu Wang
%A Xiaofei Guo
%A Xiaohan Cao
%A Xiaoyun He
%A Zhangyuan Pan
%J Archive of "Animals : an Open Access Journal from MDPI".
%D 2018
%R 10.3390/ani8110200
%X Growth differentiation factor 9 (GDF9) is an important gene for ovine fertility. GDF9 is highly expressed in the ovary as opposed to other tissues, but the reason for this is unknown. Our study found this can be caused by the methylation level of the promoter CpG island mC-4 site. This finding contributes to the understanding of the regulatory mechanism of GDF9 gene in reproduction
%K GDF9
%K methylation
%K mRNA expression
%K tissue-specific
%K regulatory mechanism
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262488/