%0 Journal Article
%T The role of protein Z and protein Z-dependent protease inhibitor polymorphisms in the development of prosthetic heart valve thrombosis
%A Macit Kal£¿£¿k
%A Mahmut Yesin
%A Mehmet Ali Astarc£¿o£¿lu
%A Mehmet £¿zkan
%A Mustafa Ozan G¨¹rsoy
%A Sabahattin G¨¹nd¨¹z
%A S¨¹leyman Karakoyun
%A Z¨¹beyde Bayram
%J Archive of "Anatolian Journal of Cardiology".
%D 2016
%R 10.14744/AnatolJCardiol.2016.6719
%X Protein Z (PZ) is a vitamin K-dependent factor, which is mainly synthesized by the liver. It acts as an activator of a serpin, namely, protein Z-dependent inhibitor (ZPI), which inhibits factor Xa. In human plasma, ZPI is present in more quantity than PZ, and PZ and PZI are present as a complex in circulation. Individuals have a wide range of normal plasma PZ concentrations, which may be partly explained by genetics (1, 2). The A-13G polymorphism in the promoter of the PZ gene, G-103A in intron A, or G-79A in intron F is associated with decreased plasma PZ level. The potential role of alterations in PZ and/or ZPI levels in the pathogenesis of thrombotic and/or hemorrhagic diseases has been previously investigated in several studies (3, 4)
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336788/