%0 Journal Article
%T Whole genome sequencing for drug resistance determination in Mycobacterium tuberculosis
%A Farzana Ismail
%A Halima M. Said
%A Lavania Joseph
%A Nabila Ismail
%A Nazir A. Ismail
%A Shaheed V. Omar
%A Thabisile L. Gwala
%J Archive of "African Journal of Laboratory Medicine".
%D 2019
%R 10.4102/ajlm.v8i1.801
%X South Africa remains challenged with a high tuberculosis burden accompanied by an increase in drug resistant cases. We assessed the use of the Illumina MiSeq, a next-generation sequencing platform for whole genome sequencing, followed by bioinformatic analysis using a commercial software package to determine resistance to selected drugs used for Mycobacterium tuberculosis treatment in our setting. Whole genome sequencing shows potential as a diagnostic platform for the detection of drug resistance in Mycobacterium tuberculosis with the provision of information for several drugs simultaneously
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407317/