%0 Journal Article %T Why Decreasing Lipophilicity Alone Is Often Not a Reliable Strategy for Extending IV Half-life %A Fabio Broccatelli %A Ignacio Aliagas %J Archive of "ACS Medicinal Chemistry Letters". %D 2018 %R 10.1021/acsmedchemlett.8b00047 %K Half-life %K clearance %K bioavailability %K LogD %K matched molecular pairs %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004569/