%0 Journal Article
%T The function of cathepsins B, D, and X in atherosclerosis
%A Caroline F Zhao
%A David M Herrington
%J Archive of "American Journal of Cardiovascular Disease".
%D 2016
%X Cathepsins are proteolytic enzymes typically located within the lysosomes of macrophages. Once released, they can enhance the inflammatory process in atherosclerosis. Cathepsin X aids in the migration of T-lymphocytes and the release of cytokines. Cathepsin D modifies low-density lipoprotein to promote its uptake by macrophages and its subsequent foam cell formation. Furthermore, cathepsin D regulates apoptosis. Cathepsin B degrades the extracellular matrix within the arterial intima. Together, they increase plaque vulnerability. This evidence suggests that cathepsins play an important role in the pathogenesis of atherosclerosis
%K Atherosclerosis
%K cathepsin
%K TNF-alpha
%K low density lipoprotein
%K apoptosis
%K vulnerable plaque
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218848/