%0 Journal Article
%T Emerging transporter-targeted nanoparticulate drug delivery systems
%A Guangxuan Liu
%A Hongyan Su
%A Qian Liu
%A Shuo Liu
%A Yan Wang
%A Yue Wang
%J Archive of "Acta Pharmaceutica Sinica. B".
%D 2019
%R 10.1016/j.apsb.2018.10.005
%X Transporter-targeted nanoparticulate drug delivery systems (nano-DDS) have emerged as promising nanoplatforms for efficient drug delivery. Recently, great progress in transporter-targeted strategies has been made, especially with the rapid developments in nanotherapeutics. In this review, we outline the recent advances in transporter-targeted nano-DDS. First, the emerging transporter-targeted nano-DDS developed to facilitate oral drug delivery are reviewed. These include improvements in the oral absorption of protein and peptide drugs, facilitating the intravenous-to-oral switch in cancer chemotherapy. Secondly, the recent advances in transporter-assisted brain-targeting nano-DDS are discussed, focusing on the specific transporter-based targeting strategies. Recent developments in transporter-mediated tumor-targeting drug delivery are also discussed. Finally, the possible transport mechanisms involved in transporter-mediated endocytosis are highlighted, with special attention to the latest findings of the interactions between membrane transporters and nano-DDS
%K Transporter
%K Nano-DDS
%K Oral delivery
%K Brain-targeting
%K Tumor-targeting
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361857/