%0 Journal Article
%T Targeting butyrylcholinesterase for preclinical single photon emission computed tomography (SPECT) imaging of Alzheimer's disease
%A Chris V. Bowen
%A Drew R. DeBay
%A Earl Martin
%A George A. Reid
%A Ian R. Pottie
%J Archive of "Alzheimer's & Dementia : Translational Research & Clinical Interventions".
%D 2017
%R 10.1016/j.trci.2017.01.005
%X Diagnosis of Alzheimer's disease (AD) in vivo, by molecular imaging of amyloid or tau, is constrained because similar changes can be found in brains of cognitively normal individuals. Butyrylcholinesterase (BChE), which becomes associated with these structures in AD, could elevate the accuracy of AD diagnosis by focusing on BChE pathology in the cerebral cortex, a region of scant BChE activity in healthy brain
%K Alzheimer's disease
%K Butyrylcholinesterase
%K Acetylcholinesterase
%K Single-photon emission computed tomography
%K Molecular imaging
%K Neuroimaging
%K 123Iodine
%K Alzheimer mouse model with 5 familial mutations
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651425/