%0 Journal Article
%T Improved de novo peptide sequencing using LC retention time information
%A Thomas Tschager
%A Tomas Hruz
%A Yves Frank
%J Archive of "Algorithms for Molecular Biology : AMB".
%D 2018
%R 10.1186/s13015-018-0132-5
%X Liquid chromatography combined with tandem mass spectrometry is an important tool in proteomics for peptide identification. Liquid chromatography temporally separates the peptides in a sample. The peptides that elute one after another are analyzed via tandem mass spectrometry by measuring the mass-to-charge ratio of a peptide and its fragments. De novo peptide sequencing is the problem of reconstructing the amino acid sequences of a peptide from this measurement data. Past de novo sequencing algorithms solely consider the mass spectrum of the fragments for reconstructing a sequence
%K Computational proteomics
%K Peptide identification
%K De novo peptide sequencing
%K Liquid chromatography
%K Mass spectrometry
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114869/