%0 Journal Article
%T A unified model for BAM function that takes into account type Vc secretion and species differences in BAM composition
%A Dirk Linke
%A Jack C. Leo
%J Archive of "AIMS Microbiology".
%D 2018
%R 10.3934/microbiol.2018.3.455
%X Transmembrane proteins in the outer membrane of Gram-negative bacteria are almost exclusively ¦Â-barrels. They are inserted into the outer membrane by a conserved and essential protein complex called the BAM (for ¦Â-barrel assembly machinery). In this commentary, we summarize current research into the mechanism of this protein complex and how it relates to type V secretion. Type V secretion systems are autotransporters that all contain a ¦Â-barrel transmembrane domain inserted by BAM. In type Vc systems, this domain is a homotrimer. We argue that none of the current models are sufficient to explain BAM function particularly regarding type Vc secretion. We also find that current models based on the well-studied model system Escherichia coli mostly ignore the pronounced differences in BAM composition between different bacterial species. We propose a more holistic view on how all OMPs, including autotransporters, are incorporated into the lipid bilayer
%K autotransport
%K protein secretion
%K Gram-negative bacteria
%K type V secretion
%K BAM
%K POTRA
%K TAM
%K outer membrane
%K transmembrane ¦Â-barrel
%K trimeric autotransporter adhesin
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604945/