%0 Journal Article
%T Optimization of a Fragment-Based Screening Hit toward
Potent DOT1L Inhibitors Interacting in an Induced Binding Pocket
%A Christian Ragot
%A Christoph Gaul
%A Clemens Scheufler
%A C¨¦line Be
%A C¨¦sar Fern¨¢ndez
%A Fr¨¦d¨¦ric Stauffer
%A Henrik M£¿bitz
%A Kim S. Beyer
%A Ralph Tiedt
%J Archive of "ACS Medicinal Chemistry Letters".
%D 2016
%R 10.1021/acsmedchemlett.6b00168
%K Dot1L
%K lysine histone methyltransferase
%K inhibitor
%K fragment-based screen
%K structure-based design
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983739/