%0 Journal Article
%T Investigation of miscellaneous hERG inhibition in large diverse compound collection using automated patch-clamp assay
%A Hai-bo Yu
%A Min Li
%A Xiao-liang Wang
%J Archive of "Acta Pharmacologica Sinica".
%D 2016
%R 10.1038/aps.2015.143
%X hERG potassium channels display miscellaneous interactions with diverse chemical scaffolds. In this study we assessed the hERG inhibition in a large compound library of diverse chemical entities and provided data for better understanding of the mechanisms underlying promiscuity of hERG inhibition
%K hERG
%K high-throughput screening
%K MLSMR library
%K automated electrophysiology
%K cardiotoxicity
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722980/