%0 Journal Article
%T Discovery of Clinical Development Candidate GDC-0084,
a Brain Penetrant Inhibitor of PI3K and mTOR
%A Alan G. Olivero
%A Bruno Alicke
%A Chudi O. Ndubaku
%A Cristina Lewis
%A Emile G. Plise
%A Jeffrey Wallin
%A Jim Nonomiya
%A Jodie Pang
%A John D. Lesnick
%A Jonathan Cheong
%A Joy Drobnick
%A Kyle Edgar
%A Lan Wang
%A Laurent Salphati
%A Leslie B. Lee
%A Stephen E. Gould
%A Steve Sideris
%A Timothy P. Heffron
%A Xiaolin Zhang
%J Archive of "ACS Medicinal Chemistry Letters".
%D 2016
%R 10.1021/acsmedchemlett.6b00005
%K PI3K
%K kinase inhibitor
%K blood£¿brain barrier penetration
%K CNS
%K oncology
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834666/