%0 Journal Article
%T Expanded Impacts of Platelet Functions: Beyond Hemostasis and Thrombosis
%A Sun Young Cho
%J Archive of "Annals of Laboratory Medicine".
%D 2019
%R 10.3343/alm.2019.39.4.343
%X Platelets are very small (2 ¦Ìm) anucleate hematologic effector cells [1] with a lifespan of approximately 8¨C10 days [2]. Platelets are traditionally well known for their primary functions in thrombosis and hemostasis [3]. The hemostasis function was first identified by Osler in 1873, who described platelets as a ¡°blood plaque¡± in the white thrombus [1]. In physiologic states, platelets are not accessible to subendothelial structures such as collagen fibers or von-Willebrand factor [4]. However, when the vessel wall is injured, the subendothelial structures are exposed, resulting in the initiation of platelet adhesion [3,4]. This interaction consequently triggers signal cascades in platelets to seal the thrombus leak at the site of vascular injury [4]. Thus, platelets have long been simply regarded as the main components of bleeding control [3,4]. In addition to this primary role of preventing blood loss from an injured vessel, the thrombus prevents the dissemination of foreign pathogens into the organism [4]
%K Platelet
%K Inflammation
%K Thrombosis
%K Hemostasis
%K Cancer
%K Biomarker
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400714/