%0 Journal Article
%T Age-Specific Cutoffs of the Sysmex UF-1000i Automated Urine Analyzer for Rapid Screening of Urinary Tract Infections in Outpatients
%A Hye Ryoun Kim
%A Hyunji Kim
%A Mi-Kyung Lee
%A Tae-Hyoung Kim
%J Archive of "Annals of Laboratory Medicine".
%D 2019
%R 10.3343/alm.2019.39.3.322
%X We investigated the usefulness of age-specific cutoffs for screening of urinary tract infections (UTIs) in Korean outpatients, using the automated urine analyzer UF-1000i (Sysmex, Kobe, Japan). We retrospectively reviewed outpatient medical records. Urine samples of 7,443 outpatients from January 2010 to December 2017 were analyzed using urine culture and UF-1000i. ROC curves were calculated for each UF-1000i parameter based on the culture results. There were 1,398 culture positive samples, 5,774 culture negative samples, and 271 contaminated samples. UF-1000i had an area under the curve of ¡Ý0.9 in outpatients >15 years. The appropriate cutoffs, which are the sum of bacterial (B-A-C) and white blood cell (WBC) counts, were 297.10/¦ÌL (15¨C24 years), 395.65/¦ÌL (25¨C44 years), 135.65/¦ÌL (45¨C64 years), 67.95/¦ÌL (65¨C74 years), and 96.5/¦ÌL (¡Ý75 years). B-A-C and WBC counts differed among the three most frequently identified bacteria (Escherichia coli, Klebsiella pneumoniae, and Enterococcus faecalis). The UF-1000i system is useful for applying age-specific cutoffs to screen for UTIs, thereby preventing antibiotic abuse and reducing antibiotic resistance. Future studies can explore how its B-A-C and WBC counts can facilitate selection of empirical antibiotics by distinguishing between gram-positive and gram-negative bacteria
%K UF-1000i
%K Urinary tract infection
%K Age-specific cutoff
%K Outpatients
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340846/