%0 Journal Article
%T Neopterin Levels and Indoleamine 2,3-Dioxygenase Activity as Biomarkers of Immune System Activation and Childhood Allergic Diseases
%A Bilge K£¿l£¿£¿arslan
%A Duygu Erge
%A Ferhat £¿atal
%A G£¿zde Girgin
%A Harika G£¿zde G£¿z¨¹kara Ba£¿
%A Song¨¹l ¨¹n¨¹var
%A Terken Baydar
%J Archive of "Annals of Laboratory Medicine".
%D 2019
%R 10.3343/alm.2019.39.3.284
%X Although Th2 immune activation is predominant in allergic diseases, neopterinlevels and indoleamine 2,3-dioxygenase (IDO)-1 activity (kynurenine:tryptophan ratio), which reflect Th1 immune activity, increase with interferon-gamma (IFN-¦Ã) stimulation. We investigated neopterin, tryptophan, and kynurenine levels as biomarkersof the Th1 immune system activation and changes in IDO-1 activityin children with asthma, allergic rhinitis, and atopic dermatitis, as well as the relationship between these biomarkers and the total IgE level, age, and disease severity
%K Allergy
%K Kynurenine
%K Neopterin
%K Tryptophan
%K Atopic dermatitis
%K Allergic rhinitis
%K Asthma
%K Th1 immune response
%K indoleamine 2
%K 3-dioxygenase activity
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340854/