%0 Journal Article
%T Retrograde interferon©\gamma signaling induces major histocompatibility class I expression in human©\induced pluripotent stem cell©\derived neurons
%A Benjamin D. S. Clarkson
%A Misha S. Patel
%A Reghann G. LaFrance©\Corey
%J Archive of "Annals of Clinical and Translational Neurology".
%D 2018
%R 10.1002/acn3.516
%X Injury©\associated axon©\intrinsic signals are thought to underlie pathogenesis and progression in many neuroinflammatory and neurodegenerative diseases, including multiple sclerosis (MS). Retrograde interferon gamma (IFN ¦Ã) signals are known to induce expression of major histocompatibility class I (MHC I) genes in murine axons, thereby increasing the susceptibility of these axons to attack by antigen©\specific CD8+ T cells. We sought to determine whether the same is true in human neurons
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817842/