%0 Journal Article
%T A summary of the Japan septic disseminated intravascular coagulation study
%A Kota Ono
%J Archive of "Acute Medicine & Surgery".
%D 2018
%R 10.1002/ams2.326
%X Over the past few decades, the large, international, randomized controlled trials of anticoagulant therapies for patients with sepsis have not yielded any improvement in mortality rates. However, in Japan, anticoagulant therapies are administered for sepsis patients with disseminated intravascular coagulation (DIC), but not for sepsis patients without DIC. Furthermore, epidemiological data regarding sepsis in Japan are scarce. Therefore, a nationwide multicenter retrospective observational study, the Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study, was undertaken. The JSEPTIC DIC study enrolled 42 intensive care units and included 3,195 patients with sepsis. The results of the JSEPTIC DIC study indicated the following: (i) anticoagulant therapy may be effective in sepsisİ\induced DIC patients at high risk for death, (ii) recombinant human soluble thrombomodulin administration and antithrombin supplementation are associated with survival benefits in patients with sepsisİ\induced DIC
%K coagulopathy
%K sepsis/multiple organ failure
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891114/