%0 Journal Article
%T Variants in the IL17 pathway genes are associated with atopic asthma and atopy makers in a South American population
%A Bruna R. Tosta
%A Camila Alexandrina Figueiredo
%A Maria B. R. de Santana
%A Maur¨ªcio L. Barreto
%A Milca de J. Silva
%A Neuza Maria Alcantara-Neves
%A Roberta P. Espinheira
%J Archive of "Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology".
%D 2019
%R 10.1186/s13223-019-0340-7
%X The role of Th17 in non-atopic asthma. In response to allergens and pollutants, epithelial cells produce cytokines that stimulate dendritic cells (DC) priming T CD4+ cells to a pro-inflammatory phenotype by the activation of RORyt transcription factor leading to the differentiation of na£¿ve T CD4+ cells into Th17 effector cells. These cells secrete IL-17A and IL-17F, which act as heterodimers in the IL-17RA and IL-17RC receptors in the epithelial cells surface. Thus, this interaction actives the NFkB that start nuclear transcription of cytokines (IL-6 and IL-8). Also, IL-8/CXCL8 induces neutrophil chemotaxi
%K Asthma
%K Atopy
%K Variants
%K IL-17 genes
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489266/