%0 Journal Article
%T Novel fluorescent probes of 10-hydroxyevodiamine: autophagy and apoptosis-inducing anticancer mechanisms
%A Chunquan Sheng
%A Guoqiang Dong
%A Na Liu
%A Shanchao Wu
%A Wannian Zhang
%J Archive of "Acta Pharmaceutica Sinica. B".
%D 2019
%R 10.1016/j.apsb.2018.08.003
%X Natural product evodiamine and its derivatives represent a promising class of multi-target antitumor agents. However, the clinical development of these compounds has been hampered by a poor understanding of their antitumor mechanisms. To tackle this obstacle, herein, novel fluorescent probes were designed to elucidate the antitumor mode of action of 10-hydroxyevodiamine. This compound was proven to be distributed in the mitochondria and lysosomes and to act by autophagy and apoptosis mechanisms
%K Boc
%K di-tert-butyl dicarbonate
%K CCK8
%K cell counting kit-8
%K DMAP
%K 4-dimethylaminopyridine
%K DMSO
%K dimethylsulfoxide
%K EDC
%K 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride
%K HBTU
%K O-benzotriazole-N
%K N
%K N
%K N-tetramethyl-uronium-hexafluorophosphate
%K 3MA
%K 3-methyladenine
%K MMP
%K mitochondrial membrane potential
%K NPs
%K natural products
%K TEA
%K trimethylamine
%K TFA
%K trifluoroacetic acid Fluorescent probes
%K 10-Hydroxyevodiamine
%K Anticancer mechanisms
%K Autophagy
%K Apoptosis
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361730/