%0 Journal Article
%T Endogenous genetic risk factor for serious heatstroke: the thermolabile phenotype of carnitine palmitoyltransferase II variant
%A Hiroshi Kido
%A Junji Chida
%A Kazunari Azuma
%A Takao Arai
%A Tetsuo Yukioka
%J Archive of "Acute Medicine & Surgery".
%D 2019
%R 10.1002/ams2.373
%X In serious heatstroke, elevated body temperature (>40ˇăC) is considered the main cause of illness. Mitochondrial carnitine palmitoyltransferase II (CPT II) plays an important role in adenosine triphosphate (ATP) generation from long©\chain fatty acids, and its thermolabile phenotype of CPT2 polymorphisms leads to ATP production loss under high fever. Whether by heatstroke or influenza, high fever suppresses mitochondrial ATP production in patients with the thermolabile phenotype of CPT2 polymorphisms. We investigated the relation between CPT2 polymorphism and severity of heatstroke with a body temperature of over 40ˇăC
%K Carnitine palmitoyltransferase II
%K coagulopathy
%K energy metabolism
%K heatstroke
%K polymorphism
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328901/