%0 Journal Article
%T Nuclear factor-kappa B: Glucocorticoid-induced leucine zipper interface analogs suppress pathology in an Alzheimer's disease model
%A Anish Thyagarajan
%A Debomoy K. Lahiri
%A Debra Hickman
%A Emily Witek
%A Mythily Srinivasan
%J Archive of "Alzheimer's & Dementia : Translational Research & Clinical Interventions".
%D 2018
%R 10.1016/j.trci.2018.04.004
%X Glucocorticoid-induced leucine zipper is a regulatory protein that sequesters activated nuclear factor-kappa B p65. Previously, we showed that rationally designed analogs of the p65-binding domain of glucocorticoid-induced leucine zipper, referred to as glucocorticoid-induced leucine zipper analogs (GAs), inhibited amyloid ¦Â¨Cinduced metabolic activity and inflammatory cytokines in mixed brain cell cultures. Here, we investigate the therapeutic efficacy of GA in an Alzheimer's disease model
%K Neuroinflammation
%K NF-¦ÊB p65 blockade
%K Neurodegeneration
%K Alzheimer's disease
%K Peptide therapeutics
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186959/