%0 Journal Article
%T Elevated phospholipase D isoform 1 in Alzheimer's disease patients' hippocampus: Relevance to synaptic dysfunction and memory deficits
%A Giulio Taglialatela
%A Rakez Kayed
%J Archive of "Alzheimer's & Dementia : Translational Research & Clinical Interventions".
%D 2018
%R 10.1016/j.trci.2018.01.002
%X Phospholipase D (PLD), a lipolytic enzyme that breaks down membrane phospholipids, is also involved in signaling mechanisms downstream of seven transmembrane receptors. Abnormally elevated levels of PLD activity are well-established in Alzheimer's disease (AD), implicating the two isoforms of mammalian phosphatidylcholine cleaving PLD (PC-PLD1 and PC-PLD2). Therefore, we took a systematic approach of investigating isoform-specific expression in human synaptosomes and further investigated the possibility of therapeutic intervention using preclinical studies
%K Phospholipase D
%K Alzheimer's disease
%K Memory
%K Synaptic
%K Hippocampus
%K Electrophysiology
%K Novel object recognition
%K A¦Â
%K Tau
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857521/