%0 Journal Article
%T Lymphoepithelioma-like carcinoma of the skin
%A Cristiano Claudino Oliveira
%A Mariangela Esther Alencar Marques
%A Vinicius Cardoso N¨®brega
%J Archive of "Anais Brasileiros de Dermatologia".
%D 2018
%R 10.1590/abd1806-4841.20187205
%X Primary cutaneous lymphoepithelioma-like carcinoma is a rare disease with low metastatic potential. Its morphologic and pathological features are similar to those of nasopharyngeal lymphoepithelial carcinoma. We report the case of a 60-year-old man with an infrapalpebral pearly papule, measuring 0.6 cm in diameter. The lesion was excised with a clinical hypothesis of basal cell carcinoma or squamous cell carcinoma. Histopathological analysis revealed a malignant neoplasm with syncytial arrangement of cells with vesicular nuclei, associated with dense lymphocytic infiltrate. Immunohistochemistry revealed cytokeratin-positive cells (AE1/AE3) and p63 protein, indicating epithelial histogenesis and squamous differentiation. A negative Epstein-Barr virus test result was achieved by immunohistochemistry. Primary lymphoepithelioma-like carcinoma of the skin is a differential diagnosis of lesions with prominent inflammatory infiltrates
%K Immunohistochemistry
%K Pathology
%K Skin neoplasms
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916400/