%0 Journal Article
%T Does antiretroviral treatment change HIV-1 codon usage patterns in its genes: a preliminary bioinformatics study
%A Bluma Brenner
%A Fr¨¦d¨¦ric Ohnona
%A Hong-Tao Xu
%A Nathan Osman
%A Navaneethan Palanisamy
%A Thibault Mespl¨¨de
%J Archive of "AIDS Research and Therapy".
%D 2017
%R 10.1186/s12981-016-0130-y
%X Codon usage bias has been described for various organisms and is thought to contribute to the regulation of numerous biological processes including viral infections. HIV-1 codon usage has been previously shown to be different from that of other viruses and man. It is evident that the antiretroviral drugs used to restrict HIV-1 replication also select for resistance variants. We wanted to test whether codon frequencies in HIV-1 sequences from treatment-experienced patients differ from those of treatment-naive individuals due to drug pressure affecting codon usage bias
%K HIV-1
%K Codon usage frequency
%K Bioinformatics
%K Antiretroviral therapy
%K Resistance
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237184/