%0 Journal Article
%T Pro- and anti-inflammatory cytokines in children with malaria in Franceville, Gabon
%A Aline Ga£¿lle Bouopda-Tuedom
%A Herman Nzoughe
%A Irene Pegha-Moukandja
%A Jean-Bernard Lekana-Douki
%A Lady Charl¨¨ne Kouna
%A Nina Tchitoula-Makaya
%A Sandrine Lydie Oyegue-Liabagui
%A Sydney Maghendji-Nzondo
%J Archive of "American Journal of Clinical and Experimental Immunology".
%D 2017
%X Severe Plasmodium falciparum malaria anemia (SMA) is a major cause of mortality in pediatric wards. Variations in inflammatory mediator production play an essential role in disease outcomes. Indeed, several studies have shown the involvement of pro- and anti-inflammatory cytokines such as IFN-¦Ã, IL-6, TNF-¦Á and IL-10 in malaria immunopathology. In other hand the exact role of Th17 cytokines such as IL-17, IL-22 and IL-21 in malaria remains poorly documented. Here, we investigated IFN-¦Ã, TNF-¦Á, IL-6, IL-12, IL-10, IL-4, IL-13, IL-17, IL-22 and IL-21 circulating levels and their association with malaria anemia and parasitemia in Gabonese children. Levels of IFN-¦Ã (500 ¡À 100.2 pg/ml), IL-6 (64 ¡À 14.2 pg/ml), IL-10 (505 ¡À 35 pg/ml), IL-13 (30.6 ¡À 5.6 pg/ml) were significantly higher (P < 0.03) in infected children than in uninfected controls (210 ¡À 20 pg/ml, 17.5 pg/ml, 50 ¡À 25.9, pg/ml, 17.48 pg/ml, respectively). IFN-¦Ã levels were significantly lower (P = 0.04) in children with SMA (400 ¡À 200 pg/ml) than in those with uncomplicated malaria (900 ¡À 450 pg/ml) and higher in those with parasitemia (P = 0.019). Levels of IL-6 and IL-10 were significantly higher in children with malarial anemia (P < 0.001) and hyperparasitemia (P < 0.0001). A significant association between IL-10 levels and parasite density was observed (P < 0.00001). IL-22 levels were significantly higher (P = 0.01) in infected children (72.57 ¡À 7.5 pg/ml) than in the controls (54.96 ¡À 1.93 pg/ml). IL-21 levels (44.46 ¡À 17.27 pg/ml) decreased with the severity of anemia (P < 0.05), whereas IL-17 levels increased in children with SMA (12.25 ¡À 1.25 pg/ml) than in those with mild malaria anemia (MMA: 6.2 ¡À 5.25 pg/ml, P = 0.002). Data suggest possible role of IFN-¦Ã in the protection against SMA and parasite clearance. However, IL-6 and IL-10 could play a role in inflammatory response and pathophysiology of severe malaria anemia. Also, the role of IL-22 and IL-17 in P. falciparum malaria infection should be investigated
%K Severe Plasmodium falciparum malaria anemia (SMA)
%K pro- and anti-inflammatory cytokines
%K children
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344990/