%0 Journal Article
%T Hyaluronan suppresses lidocaine-induced apoptosis of human chondrocytes in vitro by inhibiting the p53-dependent mitochondrial apoptotic pathway
%A Sang-Han Lee
%A Soo A Kim
%A Yoon-Jin Lee
%J Archive of "Acta Pharmacologica Sinica".
%D 2016
%R 10.1038/aps.2015.151
%X Intra-articular injection of local anesthetics (LAs) is a common procedure for therapeutic purposes. However, LAs have been found toxic to articular cartilage, and hyaluronan may attenuate this toxicity. In this study we investigated whether hyaluronan attenuated lidocaine-induced chondrotoxicity, and if so, to elucidate the underlying mechanisms
%K hyaluronan
%K lidocaine
%K intra-articular injection
%K osteoarthritis
%K chondrocytes
%K apoptosis
%K oxidative damage
%K mitochondria
%K p53
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857542/