%0 Journal Article
%T DL0805-2, a novel indazole derivative, relaxes angiotensin II-induced contractions of rat aortic rings by inhibiting Rho kinase and calcium fluxes
%A Guan-hua Du
%A Li Li
%A Lian-hua Fang
%A Ping Xie
%A Tian-yi Yuan
%A Xiao-zhen Jiao
%A Yu-cai Chen
%J Archive of "Acta Pharmacologica Sinica".
%D 2016
%R 10.1038/aps.2015.161
%X DL0805-2 [N-(1H-indazol-5-yl)-1-(4-methylbenzyl) pyrrolidine-3-carboxamide] is a DL0805 derivative with more potent vasorelaxant activity and lower toxicity. This study was conducted to investigate the vasorelaxant mechanisms of DL0805-2 on angiotensin II (Ang II)-induced contractions of rat thoracic aortic rings in vitro
%K DL0805-2
%K angiotensin II
%K vasorelaxation
%K Rho/ROCKs
%K Ca2+ fluxes
%K rat aortic ring
%K vascular smooth muscle cells
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857545/