%0 Journal Article
%T Autophagy activation prevents sevoflurane-induced neurotoxicity in H4 human neuroglioma cells
%A Gang Chen
%A Hai-yan Zhou
%A Qing-xia Wang
%A You-fa Zhou
%J Archive of "Acta Pharmacologica Sinica".
%D 2016
%R 10.1038/aps.2016.6
%X The inhaled anesthetic sevoflurane may induce cognitive impairment in both animals and humans. Previous study has shown that sevoflurane triggers ER stress and may lead to apoptosis in rat hippocampal neurons. In this study, we examined whether sevoflurane caused autophagy and its contributions to sevoflurane induced neuronal cell injury
%K sevoflurane
%K inhalation anesthetics
%K H4 human neuroglioma cells
%K autophagy
%K apoptosis
%K ER stress
%K rapamycin
%K 3-MA
%K 4-phenylbutyrate
%K neuroprotection
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857550/