%0 Journal Article
%T Aconine inhibits RANKL-induced osteoclast differentiation in RAW264.7 cells by suppressing NF-¦ĘB and NFATc1 activation and DC-STAMP expression
%A Keng Wang
%A Lei Tao
%A Long-gang He
%A Song Wang
%A Xiang-zhou Zeng
%A Xiao-juan Li
%A Yue-yang Zhang
%J Archive of "Acta Pharmacologica Sinica".
%D 2016
%R 10.1038/aps.2015.85
%X Aconiti Lateralis Radix Preparata is a traditional Chinese medicine used to treat chronic arthritis and is highly effective against rheumatoid arthritis. However, the effects of aconine, a derivative of aconitum alkaloids, on osteoclasts, which can absorb bone, remain unknown. Here, we investigated the effects of aconine on osteoclast differentiation and bone resorption in vitro
%K aconine
%K osteoclast
%K RAW264.7
%K bone resorption
%K NF-¦ĘB
%K NFATc1
%K DC-STAMP
%K osteoporosis
%K rheumatoid arthritis
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753374/