%0 Journal Article
%T Emerging Nanoİ\/Microapproaches for Cancer Immunotherapy
%A Benjamin G. Vincent
%A C. Tilden Hagan
%A IV
%A Yu Mi
%J Archive of "Advanced Science".
%D 2019
%R 10.1002/advs.201801847
%X Cancer immunotherapy has achieved remarkable clinical efficacy through recent advances such as chimeric antigen receptorİ\T cell (CARİ\T) therapy, immune checkpoint blockade (ICB) therapy, and neoantigen vaccines. However, application of immunotherapy in a clinical setting has been limited by low durable response rates and immuneİ\related adverse events. The rapid development of nanoİ\/microtechnologies in the past decade provides potential strategies to improve cancer immunotherapy. Advances of nanoİ\/microparticles such as virusİ\like size, high surface to volume ratio, and modifiable surfaces for precise targeting of specific cell types can be exploited in the design of cancer vaccines and delivery of immunomodulators. Here, the emerging nanoİ\/microapproaches in the field of cancer vaccines, immune checkpoint blockade, and adoptive or indirect immunotherapies are summarized. How nanoİ\/microparticles improve the efficacy of these therapies, relevant immunological mechanisms, and how nanoİ\/microparticle methods are able to accelerate the clinical translation of cancer immunotherapy are explored
%K adoptive immunotherapy
%K cancer immunotherapy
%K cancer vaccines
%K checkpoint blockades
%K combination immunotherapy
%K nanoparticles
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425500/