%0 Journal Article %T NIRİ\Triggered Phototherapy and Immunotherapy via an Antigenİ\Capturing Nanoplatform for Metastatic Cancer Treatment %A Ashley R. Hoover %A Benqing Zhou %A Cynthia Murray %A Feifan Zhou %A Jun Song %A Junle Qu %A Lu Wang %A Meng Wang %J Archive of "Advanced Science". %D 2019 %R 10.1002/advs.201802157 %X Combined phototherapy and immunotherapy demonstrates strong potential in the treatment of metastatic cancers. An upconversion nanoparticle (UCNP) based antigenİ\capturing nanoplatform is designed to synergize phototherapies and immunotherapy. In particular, this nanoplatform is constructed via selfİ\assembly of DSPEİ\PEGİ\maleimide and indocyanine green (ICG) onto UCNPs, followed by loading of the photosensitizer rose bengal (RB). ICG significantly enhances the RBİ\based photodynamic therapy efficiency of UCNP/ICG/RBİ\mal upon activation by a nearİ\infrared (NIR) laser, simultaneously achieving selective photothermal therapy. Most importantly, tumorİ\derived protein antigens, arising from phototherapyİ\treated tumor cells, can be captured and retained in situ, due to the functionality of maleimide, which further enhance the tumor antigen uptake and presentation by antigenİ\presenting cells. The synergized photothermal, photodynamic, and immunological effects using lightİ\activated UCNP/ICG/RBİ\mal induces a tumorİ\specific immune response. In the experiments, intratumoral administration of UCNP/ICG/RBİ\mal, followed by noninvasive irradiation with an NIR laser, destroys primary tumors and inhibits untreated distant tumors, using a poorly immunogenic, highly metastatic 4T1 mammary tumor model. With the simultaneous use of antiİ\CTLAİ\4, about 84% of the treated tumorİ\bearing mice achieve longİ\term survival and 34% of mice develop tumorİ\specific immunity. Overall, this antigenİ\capturing nanoplatform provides a promising approach for the treatment of metastatic cancers %K antigen capture %K immunotherapy %K metastatic cancer %K phototherapy %K upconversion %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523374/