%0 Journal Article
%T Oral immunotherapy with the ingestion of house dust mite extract in a murine model of allergic asthma
%A Chuan-Mu Chen
%A Hsiao-Ling Chen
%A Hsu-Chung Liu
%A Hueng-Chuen Fan
%A Tung-Chou Tsai
%A Yao-Tung Wang
%A Yen-Ching Lee
%J Archive of "Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology".
%D 2018
%R 10.1186/s13223-018-0269-2
%X Protocol of oral immunotherapy with HDM extracts ingestion in a murine model of allergic asthma. Mice were divided into 3 groups. These mice received sensitization twice by intraperitoneal (i.p.) injection of HDM extracts and Al(OH)3 on day 1 and day 8 (Groups B and C). Then, the mice received allergen challenge to induce allergic airway inflammation by intratracheal (i.t.) instillation of HDM extracts on days 29¨C31 (Groups B and C). The mice of Group C received oral immunotherapy with HDM extracts ingestion before the allergen challenge. Group A: the normal control (NC) group composed of unsensitized mice fed formula; Group B: the positive control (PC) group composed of HDM-sensitized mice, which served as the inflammation control; Group C: the treatment (HDM) group, composed of HDM-sensitized mice treated with oral immunotherapy, which served as the intervention grou
%K Allergen-specific immunotherapy
%K House dust mite
%K Allergic asthma
%K Oral immunotherapy
%K Airway inflammation
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190578/