%0 Journal Article
%T Design of the NL-ENIGMA study: Exploring the effect of Souvenaid on cerebral glucose metabolism in early Alzheimer's disease
%A Bart N.M. van Berckel
%A Charlotte E. Teunissen
%A Frederik Barkhof
%A Ingrid S. Kuyper
%A Laus M. Broersen
%A Marieke M. Lansbergen
%A Philip Scheltens
%A Ronald Boellaard
%A Wiesje M. van der Flier
%J Archive of "Alzheimer's & Dementia : Translational Research & Clinical Interventions".
%D 2016
%R 10.1016/j.trci.2016.07.004
%X Alzheimer's disease is associated with early synaptic loss. Specific nutrients are known to be rate limiting for synapse formation. Studies have shown that administering specific nutrients may improve memory function, possibly by increasing synapse formation. This Dutch study explores the Effect of a specific Nutritional Intervention on cerebral Glucose Metabolism in early Alzheimer's disease (NL-ENIGMA, Dutch Trial Register NTR4718, http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=4718). The NL-ENIGMA study is designed to test whether the specific multinutrient combination Fortasyn Connect present in the medical food Souvenaid influences cerebral glucose metabolism as a marker for improved synapse function
%K Alzheimer's disease
%K Nutritional intervention
%K Diet
%K Randomized clinical trial
%K Synapse formation
%K Synaptic activity
%K [18F]FDG-PET
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651347/